The MCS SIG is a forum for ISoP members sharing common interests in
advancing mathematical and computational techniques in pharmacometrics.
Our goals include increasing awareness within the ISoP community of
existing or emerging MCS methods, offering training in their use, and
providing guidance for rigorous and impactful applications. We also
maintain ties with mathematical communities around the world to promote
pharmacometrics as a scientific discipline generating a variety of
interesting theoretical and applied problems.
The activities of the MCS SIG are focused on the following themes:
- Networking: increase ties between the broader MCS community and
pharmacometrics including other SIGs; provide venues for learning and
- Learning: act as a resource for the pharmacometrics community,
including students, through recommended reading, courses, conference
sessions, and online discussions and materials.
- Collaboration: help identify and publicize existing MCS methods for
pharmacometrics needs; promote opportunities for MCS researchers to
develop new theories, methods, and computational tools.
Gilbert Koch (Chair)
Dr. Gilbert Koch is an interdisciplinary scientist with mathematical background. Currently he works as Senior Research Fellow in the Pediatric Pharmacology and Pharmacometrics Group at the University Children’s Hospital in Basel, Switzerland. Additionally, he holds an Adjunct Assistant Professor position at the University of New York at Buffalo, NY, USA.
Dr. Koch’s interests are pediatric and rare disease related optimal drug dosing questions, modeling of drug-drug interaction at various levels, advanced mathematical modeling techniques such as delay differential equations, mathematical rigorous optimization approaches to compute optimal dosing regimens, target-mediated drug disposition models with more drugs and more targets, and finally development of decision support tools to assist clinicians in daily practice. His PhD was sponsored by Nycomed (now Takeda) and his PostDoc at the University at Buffalo, NY, was funded by Fonds National de la Recherche Luxembourg, Marie-Curie Action.
Frank Gibbons (Vice Chair)
Dr Frank Gibbons received his PhD in physics from Northeastern University in Boston, MA, for his work developing computational models of complex systems, such as mitotic-spindle assembly. He is currently Principal Scientist in the Oncology DMPK group of AstraZeneca’s IMED Biotech Unit, based in Waltham, MA.
He has over 20 years’ experience applying computational techniques to biological systems, having published in genomics/proteomics (prediction of gene function, protein complex membership, and protein identification from tandem mass-spec). His current role involves building mechanistic pharmacokinetic/pharmacodynamic models of efficacy and toxicity to support cancer-drug development, participating in and leading external collaborations, and mentoring post-baccalaureate and post-doctoral scientists.
Craig Thalhauser (Secretary)
Dr. Craig Thalhauser is a mathematician and currently holds the position of a Director, Quantitative Systems Pharmacology (QSP) at Genmab. He received his Ph.D. in mathematics from Arizona State University after an M.S. in Cellular and Molecular Physiology from Tufts University. His work since the start of his postdoctoral fellowship has been to apply mathematical models to questions of biology to generate new hypotheses about the dynamics of a process or disease.
Prior to joining Genmab, Dr. Thalhauser was a Research Fellow in the Quantitative Clinical Pharmacology group at Bristol-Myers Squibb, where he led QSP efforts in autoimmune disease drug development. Prior to BMS, he was a mathematical modeler at Immunetrics, Inc, a biosimulation CRO specializing in QSP model development in inflammation.
Steering Committee Members
- Dean Bottino
- Jeroen Elassaiss-Schaap
- Denise Kirschner
- Ami Radunskaya
- Wojciech Krzyzanski
- Helen Moore
- Carl Panetta
- Johannes Schropp
- Tongli Zhang
- Peiying Zuo
- Justin Wilkins, ex officio
Elections are held once per year. The Vice Chair assumes the role of Chair and the Secretary assumes the role of Vice Chair when those respective positions are vacated.
Our other home on the web
Visit our homepage here for news and updates on our activities.
Are you interested in receiving updates and participating in SIG discussions? Join the ISoP MCS SIG today, click here.